"A mutation in a DNA molecule within a chromosome of a skin cell in my index finger has no influence on heredity. Fingers are not involved, at least directly, in the propagation of the species."

“Now, there has been the view that ... if there is nothing special about us in space then maybe there is something special about us in time. ... To me, the principal trouble with this idea is that 99.998% of the lifetime of the universe, from its beginning to now, was over before humans appeared on the scene.”

“I would love to believe that when I die I will live again, that some thinking, feeling, remembering part of me will continue. But much as I want to believe that, and despite the ancient and worldwide cultural traditions that assert an afterlife, I know of nothing to suggest that it is more than wishful thinking. The world is so exquisite with so much love and moral depth, that there is no reason to deceive ourselves with pretty stories for which there's little good evidence. Far better it seems to me, in our vulnerability, is to look death in the eye and to be grateful every day for the brief but magnificent opportunity that life provides.”

“It seems to me what is called for is an exquisite balance between two conflicting needs: the most skeptical scrutiny of all hypotheses that are served up to us and at the same time a great openness to new ideas ... If you are only skeptical, then no new ideas make it through to you ... On the other hand, if you are open to the point of gullibility and have not an ounce of skeptical sense in you, then you cannot distinguish the useful ideas from the worthless ones.”

“Imagine, a room, awash in gasoline. And there are two implacable enemies in that room. One of them has 9,000 matches. The other has 7,000 matches. Each of them is concerned about who's ahead, who's stronger. Well, that's the kind of situation we are actually in. The amount of weapons that are available to the United States and the Soviet Union are so bloated, so grossly in excess of what's needed to dissuade the other that if it weren't so tragic, it would be laughable.”

“It is easy to create an interstellar radio message which can be recognized as emanating unambiguously from intelligent beings. A modulated signal (‘beep,’ ‘beep-beep,’ . . . ) comprising the numbers 1, 2, 3, 5, 7, 11, 13, 17, 19, 23, 29, 31, for example, consists exclusively of the first 12 prime numbers—that is, numbers that can be divided only by 1, or by themselves. A signal of this kind, based on a simple mathematical concept, could only have a biological origin. . . . But by far the most promising method is to send pictures.”

“Modern science has been a voyage into the unknown, with a lesson in humility waiting at every stop. Many passengers would rather have stayed home.”