"One aim of the physical sciences has been to give an exact picture of the material world. One achievement of physics in the twentieth century has been to prove that that aim is unattainable. There is no absolute knowledge and those who claim it, whether they are scientist or dogmatist, open the door to tragedy. All knowledge, all information is imperfect. We have to treat it with humility."

“And I am infinitely saddened to find myself suddenly surrounded in the west by a sense of terrible loss of nerve, a retreat from knowledge into—into what? Into Zen Buddhism; into falsely profound questions about, Are we not really just animals at bottom; into extra-sensory perception and mystery. They do not lie along the line of what we are able to know if we devote ourselves to it: an understanding of man himself. We are nature’s unique experiment to make the rational intelligence prove itself sounder than the reflex. Knowledge is our destiny. Self-knowledge, at last bringing together the experience of the arts and the explanations of science, waits ahead of us.”

“I am using the word image in a wide meaning, which does not restrict it to the mind's eye as a visual organ. An image in my usage is what Charles Pierce called a sign...”

“The images play out for us events which are not present in our senses, and... create the future—a future that... may never come to exist in that form.”

“We are all afraid - for our confidence, for the future, for the world. That is the nature of the human imagination. Yet every man, every civilization, has gone forward because of its engagement with what it has set itself to do. The personal commitment of a man to his skill, the intellectual commitment and the emotional commitment working together as one, has made the Ascent of Man.”

“Christopher Columbus discovered the West Indies, and Alexander Graham Bell invented the telephone. We do not call their achievements creations because they are not personal enough. The West Indies were there all the time; and as for the telephone, we feel that Bell's ingenious thought was somehow not fundamental. The groundwork was there, and if not Bell then someone else would have stumbled on the telephone almost as accidently as on the West Indies.”

“Science is not a special sense. It is as wide as the literal meaning of its name: knowledge. The notion of the specialized mind is... as modern as the specialized man, 'the scientist', a word which is only a hundred years old.”