"I took some bad acid in November of 1965, and the after effect left me crazy and helpless for six months. My mind would drift into a place that was very electrical and crackly, filled with harsh, abrasive, low grade, cartoony, tawdry carnival visions. There was a nightmarish mechanical aspect to everyday life. My ego was so shattered, so fragmented that it didn't get in the way during what was the most unself-conscious period of my life. I was kind of on automatic pilot and was still constantly drawing. Most of my popular characters—Mr. Natural, Flaky Foont, Angelfood McSpade, Eggs Ackley, The Snoid, The Vulture Demonesses, Av' n' Gar, Shuman the Human, the Truckin' guys, Devil Girl—all suddenly appeared in the drawings in my sketchbook in this period, early 1966. Amazing! I was relieved when it was finally over, but I also immediately missed the egoless state of that strange interlude. LSD put me somewhere else. I wasn't sure where. All I know is, it was a strange place. Psychedelic drugs broke me out of my social programming. It was a good thing for me, traumatic though, and I may have been permanently damaged by the whole thing, I'm not sure. I see LSD as a positive, important life experience for me, but I certainly wouldn't recommend it to anyone else."

“For a while I was most well known for that , and for “Keep on Truckin’.” That was a drawing that came out of LSD trips, and the words came from a Blind Boy Fuller song from 1935. I drew it in my sketchbook and then for Zap. It sort of caught the popular imagination. It became a horrible popular thing.”

“I was lucky to be part of the "underground comix" thing in which cartoonists were completely free to express themselves. To function on those terms means putting everything out in the open—no need to hold anything back—total liberation from censorship, including the inner censor! A lot of my satire is considered by some to be "too hard." My "negro" characters are not about black people, but are more about pushing these "uncool" stereotypes in readers' faces, so suddenly they have to deal with a very tacky part of our human nature. … Who did I think I was appealing to? I don't know. I was just being a punk, putting down on paper all these messy parts of the culture we internalize and keep quiet about. I admit I'm occasionally embarrassed when I look at some of that work now.”

“I never had a strategy in my dealing with other humans! I've always been very passive socially. I went along with their agenda. I had none of my own! Left to my own devices I stayed in my room or wandered aimlessly in the streets, fantasizing about bizarre things I yearned to do to big ladies, or filled with self-pity and resentment. I was helpless in the presence of other people! My main concern was to make them like me by being as agreeable as possible, and secondly to impress them with my brilliance, my sharp wit, my originality, and my fundamental saintliness. Over time, and after years—decades—of diligent practice, I became very good at this cute little performance of mine. But this performance was improvised in the moment, catered to suit whoever I happened to be with. There was no strategy. It was always an effort. Only in solitude was I completely relaxed. Funny thing...”

“I was never as cocksure again after that first LSD inspiration. Especially with fame and reputation. You become very uncertain, you have to follow your own act. I never did get that kind of spontaneous cocksureness back again. It’s like going from being the observer to the observed. I had been used to being invisible when I was young. After I became well-known, it was very hard to be anonymous in the world. Of course, at first I liked all the attention. Suddenly, good-looking girls were interested in me! Wow! I couldn’t believe it.”

“As a kid growing up in the 1950s I became acutely aware of the changes taking place in American culture and I must say I didn't much like it. I witnessed the debasement of architecture, and I could see a decline in the quality of things like comic books and toys, things made for kids. Old things seemed to have more life, more substance, more humanity in them.”

“I knew I was weird by the time I was four. I knew I wasn't like other boys. I knew I was more fearful. I didn't like the rough and tumble most boys were into. I knew I was a sissy.”