"In many of Albrecht Dürer’s engravings there are harrowing depictions of his own melancholia; the manic wheeling stars of Van Gogh are the precursors of the artist’s plunge into dementia and the extinction of self. It is a suffering that often tinges the music of Beethoven, of Schumann and Mahler, and permeates the darker cantatas of Bach. The vast metaphor which most faithfully represents this fathomless ordeal, however, is that of Dante, and his all-too-familiar lines still arrest the imagination with their augury of the unknowable, the black struggle to come:"

“For in virtually any other serious sickness, a patient who felt similar devastation would be lying flat in bed, possibly sedated and hooked up to the tubes and wires of life-support systems, but at the very least in a posture of repose and in an isolated setting. His invalidism would be necessary, unquestioned and honorably attained. However, the sufferer from depression has no such option and therefore finds himself, like a walking casualty of war, thrust into the most intolerable social and family situations. There he must, despite the anguish devouring his brain, present a face approximating the one that is associated with ordinary events and companionship. He must try to utter small talk, and be responsive to questions, and knowingly nod and frown and, God help him, even smile.”

“Someday I will understand Auschwitz. This was a brave statement but innocently absurd. No one will ever understand Auschwitz.”

“For those who have dwelt in depression’s dark wood, and known its inexplicable agony, their return from the abyss is not unlike the ascent of the poet, trudging upward and upward out of hell’s black depths and at last emerging into what he saw as “the shining world.” There, whoever has been restored to health has almost always been restored to the capacity for serenity and joy, and this may be indemnity enough for having endured the despair beyond despair.”

“Tidewater traumas profile by James Campbell at The Guardian Unlimited website .”

““Surely mankind has yet to be born. Surely this is true! For only something blind and uncomprehending could exist in such a mean conjunction with its own flesh, its own kind. How else account for such faltering, clumsy, hateful cruelty? Even the possums and the skunks know better! Even the weasels and the meadow mice have a natural regard for their own blood and kin. Only the insects are low enough to do the low things that people do — like those ants that swarm on poplars in the summertime, greedily husbanding little green aphids for the honeydew they secrete. Yes, it could be that mankind has yet to be born. Ah, what bitter tears God must weep at the sight of the things that men do to other men!” He broke off then and I saw him shake his head convulsively, his voice a sudden cry: “In the name of money! Money!”

“I had now reached that phase of the disorder where all sense of hope had vanished, along with the idea of a futurity; my brain, in thrall to its outlaw hormones, had become less an organ of thought than an instrument registering, minute by minute, varying degrees of its own suffering.”