"You don't write a novel out of sheer pity any more than you blow a safe out of a vague longing to be rich. Compassion is all to the good, but vindictiveness is the verity Faulkner forgot: the organic force in every creative effort, from the poetry of Villon to the Brinks Express Robbery, that gives shape and color to all our dreams. A certain ruthlessness and a sense of alienation from society is as essential to creative writing as it is to armed robbery. The strong-armer isn't out merely to turn a fast buck any more than the poet is out solely to see his name on the cover of a book, whatever satisfaction that event may afford him. What both need most deeply is to get even. And, of course, neither will."

“Thinking of Melville, thinking of Poe, thinking of Mark Twain and Vachel Lindsay, thinking of Jack London and Tom Wolfe, one begins to feel there is almost no way of becoming a creative writer in America without being a loser.”

“Do American faces so often look so lost because they are most tragically trapped between a very real dread of coming alive to something more than merely existing, and an equal dread of going down to the grave without having done more than merely be comfortable? If so, this is the truly American disease. And would account in part for the fact that we lead the world today in insanity, criminality, alcoholism, narcoticism, psychoanalysm, cancer, homicide and perversion in sex as well as in perversion just for the pure hell of the thing. Never on the earth of man has he lived so tidily as here amidst such psychological disorder. Never has any people lived so hygienically while daily dousing itself with the ritual slops of guilt. Nowhere has any people set itself a moral code so rigid while applying it quite so flexibly.”

“The clock in the room above the Safari told only Junkie Time. For every hour here was Old Junkie's Hour and the walls were the color of all old junkies' dreams: the hue of diluted morphine in the moment before the needle draws the suffering blood. / Walls that went up and up like walls in a troubled dream. Walls like water where no legend could be written and no hand grasp metal or wood. He was falling between glacial walls, he didn't know how anyone could fall so far away from everyone else in the world. So far to fall, so cold all the way, so steep and dark between those morphine-colored walls of 's terrible pit.”

“It's every man for himself in this hired air. / Yet once you've come to be part of this particular patch, you'll never love another. Like loving a woman with a broken nose, you may well find lovelier lovelies. But never a lovely so real.”

“Never eat at a place called Mom's. Never play cards with a man named Doc. And never lay down with a woman who's got more troubles than you.”

“Well, I haven't consciously tried to develop . The only thing I've consciously tried to do was put myself in a position to hear the people I wanted to hear talk talk. I used the police lineup for I don't know how many years. I was just over on the South Side and got rolled. But they gave me a card, you know, to look for the guys in the lineup, and I used that card for something like seven years.”