"Francisco Varela is amazingly inventive, freewheeling, and creative. There's a lot of depth in what he and Humberto Maturana have said. Conversely, from the point of view of a tied-down molecular biologist, this is all airy-fairy, flaky stuff. Thus there's the mixed response. That part of me that's tough-minded and critical is questioning, but the other part of me has cottoned on to the recent stuff he's doing on self- representation in immune networks. I love it."

“Living systems exist in the solid regime near the edge of chaos, and natural selection achieves and sustains such a poised state.”

“The strange thing about the theory of evolution is that everyone thinks he understands it. But we do not. A biosphere, or an econosphere, self-consistently coconstructs itself according to principles we do not yet fathom.”

“Evolution is not just "chance caught on the wing". It is not just a tinkering of the ad hoc, of bricolage, of contraption. It is emergent order honored and honed by selection.”

“An online chat with Stuart Kauffman on a complexity organization website.”

“One of the most important presuppositions of Darwin's entire thesis is gradualism, the idea that mutations to the genome can cause minor variations in the organism's properties, which can be accumulated piecemeal, bit by bit, over the eons to create the complex order found in the organisms we observe.”

“Life does not depend on the magic of Watson-Crick base pairing or any other specific template-replicating machinery. Life lies ... in the property of catalytic closure among a collection of molecular species”