"When I was a kid, the disaster we worried about most was a nuclear war. That's why we had a barrel like this down in our basement, filled with cans of food and water. When the nuclear attack came, we were supposed to go downstairs, hunker down, and eat out of that barrel. Today, the greatest risk of global catastrophe doesn't look like this. Instead, it looks like this. If anything kills over 10 million people in the next few decades, it's most likely to be a highly infectious virus rather than a war. Not missiles, but microbes."

“The harsh mathematics of polio makes it clear: We cannot maintain a level of one thousand or two thousand cases a year. Either we eradicate polio, or we return to the days of tens of thousands of cases per year. That is no alternative at all. We don't let children die because it is fatiguing to save them. Our commitment as a foundation is to work with partners until no children die from polio.”

“Unfortunately, many programs are so big that there is no one individual who really knows all the pieces, and so the amount of code sharing you get isn't as great. Also, the opportunity to go back and really rewrite something isn't quite as great, because there's always a new set of features that you're adding on to the same program.”

“We're no longer in the days where everything is super well crafted. But at the heart of the programs that make it to the top, you'll find that the key internal code was done by a few people who really know what they were doing.”

“Understand that this is the last physical format there will ever be.”

“Just giving people devices has a really horrible track record. You really have to change the curriculum and the teacher. And it's never going to work on a device where you don't have a keyboard-type input. Students aren't there just to read things. They're actually supposed to be able to write and communicate. And so it's going to be more in the PC realm—it's going to be a low-cost PC that lets them be highly interactive.”

“If you just want to say, "Steve Jobs invented the world, and then the rest of us came along," that's fine. If you're interested, Jim Allchin will be glad to educate you feature by feature what the truth is. ... Let's be realistic, who came up with "File/Edit/View/Help"? Do you want to go back to the original Mac and think about where those interface concepts came from?”