"Are we making more mistakes now? I don't think so. Science is a high-risk activity. And when you do science—this is very important incidentally for the general public, and for policy makers—if you are not wasting some of your money, you are not doing good science. It's a funny way to say this. You've got to back high-risk opportunities. And high-risk opportunities means some fraction of them are going to fail. And I think in any science funding scenario, you've got to say, 10, 20, maybe even 30% of your funds are going to be invested in failures."

“That's the eureka moment, when suddenly you know something. Your hands sweat, you get into all kinds of symptoms of tremendous excitement. First of all, it's fear. Is it right? And it's incredible humor. 'How could it be any other way? It had to be that way! How could we have been so stupid, not to see this?'”

“Particle physics suffers more from being infected by the socio-political mood of the day than from lack of spectacular opportunities for major and profound discoveries.”

“A time traveler from the year 1899 would be continually amazed by our advanced technology—our cars and airplanes, our skyscraper cities, our TV, radio, computers, and communication abilities. Probably the traveler would be most shaken by our science, from astronomy to zoology. The only place in which this visitor would be comfortably at home is in most of our high schools.”

“Science is not about status quo. It’s about revolution.”

“The main virtue of the physics-chemistry-biology sequence is the hierarchical nature of the sciences. Physics comes first because it serves as a powerul prerequisite for chemistry and because it can more clearly illustrate the nature of the scientific process.”

“... I said I am doing experiments on pions. Einstein said, "Pions! Pions! We don't understand the electron. Why do you bother with pions? ...”