"All life on earth - everything from bacteria to mushrooms to hippos - shares an astonishing range of detailed biochemical similarities, including the structure of heredity in DNA and RNA, and the universal use of ATP as an energy-storing compound. Two possible scenarios, with markedly different implications for the nature of life, might explain these regularities: either all earthly life shares these features because no other chemistry can work, or these similarities only record the common descent of all organisms on earth from a single origin that happened to feature this chemistry as one possibility among many."

“Knowledge and wonder are the dyad of our worthy lives as intellectual beings. Voyager did wonders for our knowledge, but performed just as mightily in the service of wonder—and the two elements are complementary, not independent or opposed. The thought fills me with awe—a mechanical contraption that could fit in the back of a pickup truck, traveling through space for twelve years, dodging around four giant bodies and their associated moons, and finally sending exquisite photos across more than four light-hours of space from the farthest planet in our solar system.”

“I believe that we can still have a genre of scientific books suitable for and accessible alike to professionals and interested laypeople. The concepts of science, in all their richness and ambiguity, can be presented without any compromise, without any simplification counting as distortion, in language accessible to all intelligent people. I hope that this book can be read with profit both in seminars for graduate students and—if the movie stinks and you forgot your sleeping pills—on the businessman's special to Tokyo.”

“In all my years of teaching with Steve, I have never seen him flustered or at a loss for words—except once. In our course entitled "Thinking About Thinking," he had been presenting a lecture on the randomness of nature and referred to Einstein's famous dictum "I shall never believe that God plays dice with the world." I responded by walking up to the blackboard and writing, "Gould or God?" I then argued that if God does not play dice with the universe, as Einstein said, and if the universe is as random as the throws of honest dice, as Gould says, then there could not be a God. Hence, Gould or God? Then I sat down, leaving it to Steve to answer the challenge. He stood up and looked at the words on the blackboard. He hesitated, gathered his thoughts, and then launched into a defense of God so brilliant that even William Jennings Bryan would have been proud. It was then that I realized what a great lawyer Gould would make. As for God... ?”

“Evolution is an obstacle course not a freeway; the correct analogue for long-term success is a distant punt receiver evading legions of would-be tacklers in an oddly zigzagged path toward a goal, not a horse thundering down the flat.”

“I can only look from the outside . I am stuck with a panoply of ineluctably indirect methods - some very sophisticated to be sure. I can atomize, experiment, and infer. I can record reams of data about behaviors and responses. But if I could be a beetle or a bacillus for that one precious minute - and live to tell the tale in perfect memory - then I might truly fulfill Darwin's dictum penned into an early notebook containing the first full flowering of his evolutionary ideas during the late 1830's: "He who understands the baboon would do more towards metaphysics than Locke.”

“I relish the fact that we New Yorkers talk funny, and that art deco skyscrapers symbolize our city. But we must set boundaries to this love of variety. I accept the need, even the blessings, of standardization in practical matters: we require a worldwide telephone dialing system and a network of national highways . We need domains of standardization, and realms of regionalism, each in its appropriate place, and linked in mutual respect and recognition. I accept and even want McDonalds at the highway interchange—but not in my little neighborhood of ethnic restaurants, and not next to the Corn Palace in Mitchell, South Dakota.”