"There's a tremendous popular fallacy which holds that significant research can be carried out by trying things. Actually it is easy to show that in general no significant problem can be solved empirically, except for accidents so rare as to be statistically unimportant. One of my jests is to say that we work empirically — we use bull's eye empiricism. We try everything, but we try the right thing first!"

“The role of science is to be systematic, to be accurate, to be orderly, but it certainly is not to imply that the aggregated, successful hypotheses of the past have the kind of truth that goes into a number system.”

“The fact that civilization is becoming more intricate must not mean that we treat men for a longer period as immature. Does it not mean, perhaps, the opposite: that we must skillfully make them mature sooner, that we must find ways of handling the intricacy of our culture?”

“In thinking about what the human animal might have gone through in the evolutionary process, have you wondered how some of the small changes which must have occurred could have had survival value? Haven't you wondered how they could have survived, when, in all of our experimental work every small change we make dies? … How many changes must have occurred in the human eye, occurred and died, before one change came along — an apparently trivial change … that gave the whole animal a significant increase in its power to perceive and hunt down its enemies and find its food. This is the kind of change that survives.”

“It was not a question of the ineptitude that might be revealed by the truth, or the possible damage that the whole program of negotiation for peace may have suffered … and it was not a question of whether with foresight that particular crisis could have been avoided. The issue was this: Does an American, when he represents all Americans, have to tell the truth at any cost? The answer is yes, and the consequence of the answer is that our techniques for influencing the rest of the world cannot be rich and flexible like the techniques of our competitors. We can be dramatic, even theatrical; we can be persuasive; but the message we are telling must be true.”

“A contemporary man who has not participated intimately in actual work in science is, in my opinion, not a modern man. I believe that this experience in science should come early in the life of all of our pupils.”

“We have not found anti-intellectualism a problem at the Polaroid Corporation, except in the very initial state of penetration. It only takes a day to change someone from an anti-intellectual to an intellectual by persuading him that he might be one!”