"The art of concluding from experience and observation consists in evaluating probabilities, in estimating if they are high or numerous enough to constitute proof. This type of calculation is more complicated and more difficult than one might think. It demands a great sagacity generally above the power of common people. The success of charlatans, sorcerors, and alchemists — and all those who abuse public credulity — is founded on errors in this type of calculation."

“I am much obliged by the kind present you have made us of your edition of Vattel. It came to us in good season, when the circumstances of a rising state make it necessary frequently to consult The Law of Nations. Accordingly, that copy which I kept, (after depositing one in our own public library here, and sending the other to the college of Massachusetts Bay, as you directed,) has been continually in the hands of the members of our congress, now sitting, who are much pleased with your notes and preface, and have entertained a high and just esteem for their author.”

“[A] great Empire, like a great Cake, is most easily diminished at the Edges.”

“Can sweetening our tea, &c. with sugar, be a circumstance of such absolute necessity? Can the petty pleasure thence arising to the taste, compensate for so much misery produced among our fellow creatures, and such a constant butchery of the human species by this pestilential detestable traffic in the bodies and souls of men?—Pharisaical Britain! to pride thyself in setting free a single Slave that happens to land on thy coasts, while thy Merchants in all thy ports are encouraged by thy laws to continue a commerce whereby so many hundreds of thousands are dragged into a slavery that can scarce be said to end with their lives, since it is entailed on their posterity!”

“[Referring to private hospital funding alone:] That won't work, it will never be enough, good health care costs a lot of money, remembering 'the distant parts of this province' in which 'assistance cannot be procured, but at an expense that neither [the sick-poor] nor their townships can afford.' ... '[This] seems essential to the true spirit of Christianity, and should be extended to all in general, whether deserving or undeserving, as far as our power reaches.'”

“[T]he waters moved away from the North American Coast towards the coasts of Spain and Africa, whence they get again into the Power of the Trade Winds, and continue the Circulation. ...so long and so strong a Current as that of the Gulph Stream, thro' all the Latitudes of variable Winds, can only be accounted for, by its having a considerable Descent, and moving from Parts where the Water is higher, to Parts where it is lower.”

“How much more than is necessary do we spend in Sleep! forgetting that The sleeping Fox catches no Poultry,[Sept. 1743] and that there will be sleeping enough in the Grave,[Sept. 1741] as Poor Richard says.”