"Systems science is a science whose domain of inquiry consists of those properties of systems and associated problems that emanate from the general notion of systemhood."

“The term “system” is unquestionably one of the most widely used terms not only in science, but in other areas of human endeavor as well. It is a highly overworked term, which enjoys different meanings under different circumstances and for different people. However, when separated from its specific connotations and uses, the term "system" is almost never explicitly defined.”

“The emergence of computer technology in World War II and its rapidly growing power in the second half of this century made it possible to deal with increasingly complex problems, some of which began to resemble the notion of organized complexity. Initially, it was the common belief of many scientists that the level of complexity we can handle is basically a matter of the level of computational power at our disposal. Later, in the early 1960s, this naive belief was replaced with a more realistic outlook.”

“Among the various paradigmatic changes in science and mathematics in this century, one such change concerns the concept of uncertainty. In science, this change has been manifested by a gradual transition from the traditional view, which insists that uncertainty is undesirable in science and should be avoided by all possible means, to an alternative view, which is tolerant of uncertainty and insists that science cannot avoid it. According to the traditional view, science should strive for certainty in all its manifestations ; hence, uncertainty is regarded as unscientific. According to the alternative view, uncertainty is considered essential to science; it is not only an unavoidable plague, but it has, in fact, a great utility.”

“The need for a fundamentally different approach to the study of physical processes at the molecular level motivated the development of relevant statistical methods, which turned out to be applicable not only to the study of molecular processes , but to a host of other areas such as the actuarial profession, design of large telephone exchanges, and the like. In statistical methods, specific manifestations of microscopic entities are replaced with their statistical averages, which are connected with appropriate macroscopic variables. The role played in Newtonian mechanics by the calculus, which involves no uncertainty, is replaced in statistical mechanics by probability theory, a theory whose very purpose is to capture uncertainty of a certain type.”

“What is systems science? This question, which I have been asked on countless occasions, can basically be answered either in terms of activities associated with systems science or in terms of the domain of its inquiry. The most natural answers to the question are, almost inevitably, the following definitions:”

“Applying this approach, systems belonging to different scientific disciplines are investigated in their natural forms. On the basis of experimental results, isomorphic relations between different systems are studied and, finally, some general principles applicable for all systems of a certain class are formulated.”