"I think our lyrics reflect reality. Maybe not someone else's reality, but definitely ours, you know? I don't write about bullshit and neither does my guitar player, Jerry Cantrell. I have a fascination with how brainwashed people get with religion and how they'll give up their money, their time and their whole life for a cause that they're sure is right, but I'm sure is wrong. I think there's a lot of people who are scared of life and living and they want to make sure they get to Heaven or whatever. I try to stay away from it as much as I can. I was raised in the church until I was 16 and I've disagreed with their beliefs as long as I can remember, so when I had the choice I chose not to believe in anything apart from myself."

“Once it got really big with Nirvana, Pearl Jam and Soundgarden, there wasn't much mentioned about us. All those bands put out records around the same time, and we hadn't put one out in two years. I don't think it hurt us, though. I'm glad we didn't get lumped together with them, because we're not those other bands.”

“The facts are that I was shooting a lot of dope, and that's nobody's business but mine. I'm not shooting dope now, and I haven't for a while.... I took a fucking long, hard walk through hell. I decided to stop because I was miserable doing it. The drug didn't work for me anymore. In the beginning I got high, and it felt great; by the end it was strictly maintenance, like food I needed to survive. Since I quit doing it, I tried it a couple of times to see if I could recapture the feeling I once got off it, but I don't. Nothing attracts me to it anymore. It was boring.”

“I know that the guys in this band would do anything for me and I'd do the same for them. I know that I can trust them, and I think now they know that they can trust me.”

“He was a one-of-a-kind singer. A lot of guys nowadays try to sound like him, but nobody can sound like him.”

“We are deeply saddened by the passing of Layne Staley, a true original who will no doubt be remembered within the pantheon of rock's all-time greats. We stand in solidarity with our brother Jerry Cantrell in this hour of mourning and send our most heartfelt condolences to all of Layne's family, friends, and fans throughout the world. Today is a tragic day for those of us who know the difference between 'My Sacrifice' and 'Them Bones', between 'How You Remind Me', and 'Rain When I Die'.”

“I was sitting with a friend one time, and I blanked out for about a minute. I had no control over my muscles, and it scared the shit out of me because I experienced what I guess could have been hell or, you know, purgatory or whatever. It was freezing cold, and I was spinning like I was drunk and trying desperately to take a breath. There was chest pain like I was gonna explode. If you gotta feel pain here, you gotta feel it somewhere else. I believe that there’s a wonderful place to go to after this life, and I don’t believe there’s eternal damnation for anyone. I’m not into religion, but I have a good grasp on my spirituality. I just believe that I’m not the greatest power on this earth. I didn’t create myself, because I would have done a hell of a better job.”