"I was taking LSD periodically, every couple of months. I was in a strange state of mind, influenced by these visions. … I was trying to draw it in my sketchbook, and that began to coalesce into these comic strips that were stylistically based on grotesque, vulgar humor comics of the thirties and forties. … All of those characters came out of that crazy visionary period that I couldn’t shut off. It was spontaneous, but I was so crazy, I was really out of my mind, it was like schizophrenia. It was like what produces art by crazy people in a madhouse. Anything could be an influence, anything I heard. I was in Chicago in early ’66 and the radio was on, there was some tune playing, it was a black station, and this announcer said, That was Mr. Natural. I just started drawing Mr. Natural, this bearded guru-type character in my sketchbook, it just came out."

“For a while I was most well known for that , and for “Keep on Truckin’.” That was a drawing that came out of LSD trips, and the words came from a Blind Boy Fuller song from 1935. I drew it in my sketchbook and then for Zap. It sort of caught the popular imagination. It became a horrible popular thing.”

“I was lucky to be part of the "underground comix" thing in which cartoonists were completely free to express themselves. To function on those terms means putting everything out in the open—no need to hold anything back—total liberation from censorship, including the inner censor! A lot of my satire is considered by some to be "too hard." My "negro" characters are not about black people, but are more about pushing these "uncool" stereotypes in readers' faces, so suddenly they have to deal with a very tacky part of our human nature. … Who did I think I was appealing to? I don't know. I was just being a punk, putting down on paper all these messy parts of the culture we internalize and keep quiet about. I admit I'm occasionally embarrassed when I look at some of that work now.”

“I never had a strategy in my dealing with other humans! I've always been very passive socially. I went along with their agenda. I had none of my own! Left to my own devices I stayed in my room or wandered aimlessly in the streets, fantasizing about bizarre things I yearned to do to big ladies, or filled with self-pity and resentment. I was helpless in the presence of other people! My main concern was to make them like me by being as agreeable as possible, and secondly to impress them with my brilliance, my sharp wit, my originality, and my fundamental saintliness. Over time, and after years—decades—of diligent practice, I became very good at this cute little performance of mine. But this performance was improvised in the moment, catered to suit whoever I happened to be with. There was no strategy. It was always an effort. Only in solitude was I completely relaxed. Funny thing...”

“I was never as cocksure again after that first LSD inspiration. Especially with fame and reputation. You become very uncertain, you have to follow your own act. I never did get that kind of spontaneous cocksureness back again. It’s like going from being the observer to the observed. I had been used to being invisible when I was young. After I became well-known, it was very hard to be anonymous in the world. Of course, at first I liked all the attention. Suddenly, good-looking girls were interested in me! Wow! I couldn’t believe it.”

“As a kid growing up in the 1950s I became acutely aware of the changes taking place in American culture and I must say I didn't much like it. I witnessed the debasement of architecture, and I could see a decline in the quality of things like comic books and toys, things made for kids. Old things seemed to have more life, more substance, more humanity in them.”

“I knew I was weird by the time I was four. I knew I wasn't like other boys. I knew I was more fearful. I didn't like the rough and tumble most boys were into. I knew I was a sissy.”