"If, however, one factor is too successful, it will continue to be the winning factor regardless of the variation in the other factors over the range of variation in the conditions, and therefore will stifle the development of other advantageous factors until the conditions change sufficiently that it no longer is the winning factor. At this point, the whole population is ill prepared for the change, and may well perish entirely if the winning factor accidentally becomes the matching factor for a disease or a predator."

“So pardon my cynical twist, but what are you doing with that 20,000×20,000 double-precision floating point matrix you say you need to invert today? If you answer "nutt'n, I jus kinda wondered what it'd be like, you know", you should be very happy that I am most likely more than 3000 miles away from you, or I would come over and slap you hard.”

“Ignoring for a moment the power of the American Medical Association, we still wouldn't see a huge amount of books on neurosurgery for dummies in 21 days or whatever. It's just plain inappropriate, and it's intentionally out of people's reach.”

“I'm bothered by the fact that stupid people don't spontaneously combust, which they should.”

“The clumsiness of people who have to engage their brain at every step is unbearably painful to watch, at least to me, and that's what the novice-friendly software makes people do, because there's no elegance in them, it's just a mass of features to be learned by rote. However, this suits people a hell of a lot better than setting out at age 6 to become a great ballet dancer and achieving their goal 20 years later after every tendon and muscle and joint has been asked to perform just a little bit more than nature ever intended over and over and over again. To most people, this is insanity. But in reality, it's art, and it's the art in what we do that makes us human.”

“If the syntax is good enough for the information, it should be good enough for the meta-information.”

“They don't make poles long enough for me want to touch Microsoft products, and I don't want any mass-marketed game-playing device or Windows appliance near my desk or on my network. This is my workbench, dammit, it's not a pretty box to impress people with graphics and sounds. When I work at this system up to 12 hours a day, I'm profoundly uninterested in what user interface a novice user would prefer.”