"While McMurphy laughs. Rocking farther and farther backward against the cabin top, spreading his laugh out across the water — laughing at the girl, at the guys, at George, at me sucking my bleeding thumb, at the captain back at the pier... and the Big Nurse and all of it. Because he knows you have to laugh at the things that hurt you just to keep yourself in balance, just to keep the world from running you plumb crazy. He knows there's a painful side; he knows my thumb smarts and his girlfriend has a bruised breast and the doctor is losing his glasses, but he won't let the pain blot out the humor no more'n he'll let the humor blot out the pain."

“You can't trust the quality any more...”

“A TV crew came over 10 years or so ago, on the anniversary of the discovery of LSD, and those guys were trying to push me towards saying how bad it was. They wanted me to talk about the dark underbelly of the drug culture. And I said, I'm not going to talk about that because I've never seen it, except in kids doing stuff that I don't know about and I'm not interested in... I've never taken crack and I've never taken ecstasy; none of us has. I don't want to take some strange drug and end up chewing my tongue for 12 hours.”

“When people ask me about LSD, I always make a point of telling them you can have the shit scared out of you with LSD because it exposes something, something hollow. Let’s say you have been getting on your knees and bowing and worshiping; suddenly, you take LSD and you look and there’s just a hole, there’s nothing there. The Catholic Church fills this hole with candles and flowers and litanies and opulence. The Protestant Church fills it with hand-wringing and pumped-up squeezing emotions because they can’t afford the flowers and the candles. The Jews fill this hole with weeping and browbeating and beseeching of the sky: How long, how long are you gonna treat us like this? The Muslims fill it with rigidity and guns and a militant ethos. But all of us know that’s not what is supposed to be in that hole. After I had been at Stanford two years, I was into LSD. I began to see that the books I thought were the true accounting books — my grades, how I’d done in other schools, how I’d performed at jobs, whether I had paid off my car or not — were not at all the true books. There were other books that were being kept, real books. In those real books is the real accounting of your life.”

“I can't help it. I was born a miscarriage. I had so many insults I died. I was born dead. I can't help it.... I'm tired.”

“I'm for mystery, not interpretive answers. … The answer is never the answer. What's really interesting is the mystery. If you seek the mystery instead of the answer, you'll always be seeking. I've never seen anybody really find the answer, but they think they have. So they stop thinking. But the job is to seek mystery, evoke mystery, plant a garden in which strange plants grow and mysteries bloom. The need for mystery is greater than the need for an answer.”

“What worries me, Billy," she said — I could hear the change in her voice — "is how your mother is going to take this.”