"During electroconvulsive therapy the blood-brain barrier is opened and during the time that it remains open there are heroically high levels of circulating pituitary hormones. Thus there is every reason to believe that... it delivers hormones to the brain..."

“Despite the effectiveness of electroconvulsive therapy... it may cause long-lasting problems with short-term memory. ...Yet despite the protests, the ability of cortisol studies to identify patients who will benefit from ECT guarantees that more patients will receive it.”

“The belief that electricity, the fourth of the modern forces, is the stuff of thought has permeated brain science since the late 1700s. ...while the brain was regarded as 'dry', all other organs were conceived as 'wet'. Doubtless the study of brain electricity helped in understanding the internal circuits of the brain, but it solved few problems of brain disease.”

“Gone are the days when scientists believed one hormone was made by one gland. Insulin, for example... is made in other surprising places, like the brain, and even by tiny one-cell organisms without a pancreas.”

“The measurement of hormones in the bloodstream of patients will not reflect the endocrine activity of the brain.”

“Animal experiments have confirmed the necessity of delivering hormones into the ventricle: the powerful hormone endorphin does not change behaviour if it is given intravenously; vasopressin will improve memory in animals only if it given into the ventricles; insulin given through the bloodstream does not control apetite but it is the best hormone for such control if given into the brain; and bombesin... only stops stomach ulceration if given into the brain.”

“Electroconvulsive therapy, or ECT, is the best therapy for unipolar depression that exists. ...they have found that the smile will return to the face of the patient on the very same day that cortisol dynamics return to normal.”