"I can remember the night that I suddenly realized what it was like to be crazy, or nights when my feelings and perceptions were of a religious nature. I had a very accurate sense that these feelings and perceptions, written down casually, would not stand the usual critical scrutiny that is my stock in trade as a scientist. If I find in the morning a message from myself the night before informing me that there is a world around us which we barely sense, or that we can become one with the universe, or even that certain politicians are desperately frightened men, I may tend to disbelieve; but when I'm high I know about this disbelief. And so I have a tape in which I exhort myself to take such remarks seriously. I say "Listen closely, you sonofabitch of the morning! This stuff is real!" I try to show that my mind is working clearly; I recall the name of a high school acquaintance I have not thought of in thirty years; I describe the color, typography, and format of a book in another room and these memories do pass critical scrutiny in the morning. I am convinced that there are genuine and valid levels of perception available with cannabis which are, through the defects of our society and our educational system, unavailable to us without such drugs. Such a remark applies not only to self-awareness and to intellectual pursuits, but also to perceptions of real people, a vastly enhanced sensitivity to facial expression, intonations, and choice of words which sometimes yields a rapport so close it's as if two people are reading each other's minds."

“Now, there has been the view that ... if there is nothing special about us in space then maybe there is something special about us in time. ... To me, the principal trouble with this idea is that 99.998% of the lifetime of the universe, from its beginning to now, was over before humans appeared on the scene.”

“I would love to believe that when I die I will live again, that some thinking, feeling, remembering part of me will continue. But much as I want to believe that, and despite the ancient and worldwide cultural traditions that assert an afterlife, I know of nothing to suggest that it is more than wishful thinking. The world is so exquisite with so much love and moral depth, that there is no reason to deceive ourselves with pretty stories for which there's little good evidence. Far better it seems to me, in our vulnerability, is to look death in the eye and to be grateful every day for the brief but magnificent opportunity that life provides.”

“It seems to me what is called for is an exquisite balance between two conflicting needs: the most skeptical scrutiny of all hypotheses that are served up to us and at the same time a great openness to new ideas ... If you are only skeptical, then no new ideas make it through to you ... On the other hand, if you are open to the point of gullibility and have not an ounce of skeptical sense in you, then you cannot distinguish the useful ideas from the worthless ones.”

“Imagine, a room, awash in gasoline. And there are two implacable enemies in that room. One of them has 9,000 matches. The other has 7,000 matches. Each of them is concerned about who's ahead, who's stronger. Well, that's the kind of situation we are actually in. The amount of weapons that are available to the United States and the Soviet Union are so bloated, so grossly in excess of what's needed to dissuade the other that if it weren't so tragic, it would be laughable.”

“It is easy to create an interstellar radio message which can be recognized as emanating unambiguously from intelligent beings. A modulated signal (‘beep,’ ‘beep-beep,’ . . . ) comprising the numbers 1, 2, 3, 5, 7, 11, 13, 17, 19, 23, 29, 31, for example, consists exclusively of the first 12 prime numbers—that is, numbers that can be divided only by 1, or by themselves. A signal of this kind, based on a simple mathematical concept, could only have a biological origin. . . . But by far the most promising method is to send pictures.”

“Since, in the long run, every planetary society will be endangered by impacts from space, every surviving civilization is obliged to become spacefaring — not because of exploratory or romantic zeal, but for the most practical reason imaginable: staying alive.”