"Murrow taking on McCarthy was one of the great high points in broadcast journalism, along with Cronkite stepping out from behind his desk and talking about how Vietnam doesn't work were two moments in broadcast journalism that you could point directly to and say actually changed American policy... I don't know a reporter that doesn't want to break a big news story. It is constantly the battle between commerce and news, or keeping entertainment from pushing the news off the air... I was looking to open a debate, to have a discussion, to be able to talk about issues that I think are important. It's simply saying, as Murrow says in the film, we have to find a way to find a safe place between the protection of the individual and the protection of the state at the same time."

“The hardest thing is trying not to correct everything on the Internet. It'd be night and day—wrong, wrong, wrong, wrong. So you just have to say, "All right, I'll take it, bring it on.”

“George Clooney at AskMen.com”

“I'm terrified of waking up at 65 years old, which is getting closer, and to wake up and say I didn't do the things that I was supposed to do... as a citizen... As someone who is well-known, I... can help bring focus... And I try to, as a son of a journalist, when I take on those causes, to be really well informed so that they can't marginalize you or make you an idiot along the way.”

“Yes, I think it’s an obscene amount of money. You know we had some protesters last night when we pulled up in San Francisco – and they’re right to protest, they’re absolutely right, it’s an obscene amount of money. The Sanders campaign, when they talk about it, is absolutely right, it’s ridiculous that we should have this kind of money in politics, I agree.”

“It's easy to work with Mark . He doesn't complain, he shows up, does his job and he's easygoing. But the main reason I keep wanting him to get hired is he has some pictures of me with a farm animal! I've had him for almost 14 years — my longest relationship to date.”

“I want to be the George Clooney of music.”