"One of the complaints leveled against me is, "Oh, Bill, you're such a meanie. Why do you have to go after religion? It gives people comfort; it doesn't hurt anything." Okay, well, other than most wars, the Crusades, the Inquisition, 9/11, arranged marriages to minors, blowing up girls' schools, the suppression of women and homosexuals, fatwas, ethnic cleansing, honor rape, human sacrifice, burning witches, suicide bombings, condoning slavery, and the systematic fucking of children, there's a few little things I have a problem with."

“… even scarier is why people have stopped thinking global warming is real. One major reason, pollsters say, is, "we had a very cold, snowy winter". Which is like saying the sun might not be real because last night it got dark.”

“The Partnership for a Drug Free America? Please, make me laugh and gag at the same time with that title. They're a lobbying arm for the liquor and prescription drug industries. They don't want a drug-free America, they want an America free of the drugs that are their competition. Prozac doesn't want to go up against marijuana, it will lose.”

“They keep pushing the idea, "The only reliable way to prevent pregnancy is to not have sex at all, because, condoms? Ooh, very unreliable, condoms break all the time." Okay. I've been using these things for thirty-five years. I've never had one condom break. Either I'm the luckiest son-of-a-bitch who ever lived--and I'm not--or this is the most reliable product since the toaster.”

“Please stop assuming that longevity and perfect health is always the correct option. No. Sometimes fun costs ya. It just does, you know? And that's OK, you're willing to make that purchase. Sammy Davis, Jr. was 64 when he died. Give me 64 Sammy-years, I'll be happy.”

“I want to thank some very special people without whom I would not be here today. George Bush, Sarah Palin and the Pope. When I came to Hollywood in 1983, I had one dream— to sleep with Jodie Foster. That didn't work out, but this is nice, too.”

“I wouldn't touch a hot dog unless you put a condom on it! You realize that the job of a hot dog is to use parts of the animal that the Chinese can't figure out how to make into a belt?”